This chain of hotels has placed their Stuttgart accommodation in the center city. The Best Western Hotel Stuttgart 21 is 1.5 km from the Killesberg Exhibition Cent, and within walking distance to the Royal Zoo and shopping district. The Best Western Hotel Stuttgart 21 is served by the Friedhofstraße metro stop. It is a 20 minute drive from the hotel to the airport.

The Best Western Hotel Stuttgart 21 offers rooms in multiple classes, with the deluxe double rooms offering fireplaces. En suite bathrooms are standard in all, as well as Internet, data ports, and coffeemakers.

The Best Western Hotel Stuttgart 21 is a four story hotel with a pale exterior and dark wood interior. Renovations to the restaurant were completed in the first quarter of 2009, and it is back to serving regional dishes. A breakfast buffet is offered daily. The front desk has business support capabilities. Relaxation amenities are a high point for the hotel, with an indoor swimming pool, Finnish sauna, tanning bed, and massage room.